Germline Profiling and Molecular Characterization of Early Onset Metastatic Colorectal Cancer

Germline Profiling and Molecular Characterization of Early Onset Metastatic Colorectal Cancer

BackgroundEarly onset colorectal cancer (EO CRC) is a heterogeneous colorectal cancer subtype with obvious hereditary tendencies and increasing incidence. We sought to determine the susceptibility genes and molecular characteristics of EO CRC.Methods330 EO metastatic CRC (mCRC) (≤55 years) and 110 a...

Full description

Bibliographic Details
Main Authors:	Ting Xu, Yinjie Zhang, Jing Zhang, Changsong Qi, Dan Liu, Zhenghang Wang, Yanyan Li, Congcong Ji, Jian Li, Xuan Lin, Ting Hou, Hao Liu, Lu Zhang, Han Han-Zhang, Lin Shen, Xicheng Wang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-10-01
Series:	Frontiers in Oncology
Subjects:	early onset colorectal cancer susceptibility gene genomic alternation prognosis next generation sequencing
Online Access:	https://www.frontiersin.org/article/10.3389/fonc.2020.568911/full

Similar Items

Pathogenic Germline Mutations of DNA Repair Pathway Components in Early-Onset Sporadic Colorectal Polyp and Cancer Patients
by: Pi-Yueh Chang, et al.
Published: (2020-11-01)

New Pathogenic Germline Variants in Very Early Onset and Familial Colorectal Cancer Patients
by: Malene Djursby, et al.
Published: (2020-09-01)

Disparities in Early-Onset Colorectal Cancer
by: Charles Muller, et al.
Published: (2021-04-01)

Identification of New Genes Involved in Germline Predisposition to Early-Onset Gastric Cancer
by: Cristina Herrera-Pariente, et al.
Published: (2021-01-01)

Early‐onset colorectal cancer in young individuals
by: Gianluca Mauri, et al.
Published: (2019-02-01)

Clinical Characteristics and Outcomes of Colorectal Cancer in the ColoCare Study: Differences by Age of Onset
by: Caroline Himbert, et al.
Published: (2021-07-01)

Genetic Analysis of Chinese Patients with Early-Onset Dementia Using Next-Generation Sequencing
by: Han LH, et al.
Published: (2020-10-01)

Red flag symptoms: detailed account of clinicopathological features in young-onset colorectal cancer
by: Ramish Riaz, et al.
Published: (2017-04-01)

Case Report: Coinheritance of Germline Mutations in APC and BRCA1 in Colorectal Cancer
by: Wei Huang, et al.
Published: (2021-03-01)

Glyceraldehyde-3-phosphate dehydrogenase is overexpressed in colorectal cancer onset
by: Míriam Tarrado-Castellarnau, et al.
Published: (2017-06-01)

Young-Onset Early Colorectal Cancer Had Similar Relative Survival to but Better Overall Survival Than Conventional Early Colorectal Cancer: A Large Population-Based Study
by: Jin-Nan Chen, et al.
Published: (2020-02-01)

Defining Early-Onset Colon and Rectal Cancers
by: Daniel Jacobs, et al.
Published: (2018-11-01)

Clinical and Molecular Comparative Study of Colorectal Cancer Based on Age-of-Onset and Tumor Location: Two Main Criteria for Subclassifying Colorectal Cancer
by: Edurne Álvaro, et al.
Published: (2019-02-01)

Clinicopathologic Factors Associated with Mismatch Repair Status Among Filipino Patients with Young-Onset Colorectal Cancer
by: Sacdalan DL, et al.
Published: (2021-03-01)

DNA Methylation Signatures and the Contribution of Age-Associated Methylomic Drift to Carcinogenesis in Early-Onset Colorectal Cancer
by: Jihoon E. Joo, et al.
Published: (2021-05-01)

Genetic impact of methylenetetrahydrofolate reductase (MTHFR) polymorphism on the susceptibility to colorectal polyps: a meta-analysis
by: Manyi Sun, et al.
Published: (2019-05-01)

<i>APC</i> Mutations Are Not Confined to Hotspot Regions in Early-Onset Colorectal Cancer
by: Alan Aitchison, et al.
Published: (2020-12-01)

VERY EARLY AND EARLY ONSET SCHIZOPHRENIA SPECTRUM DISORDERS – DIAGNOSTIC CHALLENGE
by: Ilinca Untu, et al.
Published: (2015-03-01)

Outcomes of Patients with Early Onset Colorectal Cancer Treated in a UK Specialist Cancer Center
by: Alexandros Georgiou, et al.
Published: (2019-10-01)

Clinical, Pathological and Molecular Characteristics of Chilean Patients with Early-, Intermediate- and Late-Onset Colorectal Cancer
by: Karin Alvarez, et al.
Published: (2021-03-01)

Efficient strategy for the molecular diagnosis of intractable early-onset epilepsy using targeted gene sequencing
by: John Hoon Rim, et al.
Published: (2018-02-01)

Next-Generation Sequencing Screening of 43 Families with Non-Syndromic Early-Onset High Myopia: A Clinical and Genetic Study
by: Arruti, N., et al.
Published: (2022)

Next-Generation Sequencing Screening of 43 Families with Non-Syndromic Early-Onset High Myopia: A Clinical and Genetic Study
by: Arruti, N., et al.
Published: (2022)

Clinicopathologic features and treatment efficacy of Chinese patients with BRAF-mutated metastatic colorectal cancer: a retrospective observational study
by: Xicheng Wang, et al.
Published: (2017-10-01)

WRN Germline Mutation Is the Likely Inherited Etiology of Various Cancer Types in One Iranian Family
by: Mahnaz Norouzi, et al.
Published: (2021-06-01)

<it>MUTYH </it>Mutations Do Not Cause HNPCC or Late Onset Familial Colorectal Cancer
by: Stormorken Astrid, et al.
Published: (2006-05-01)

Financial burden and quality of life among early‐onset colorectal cancer survivors: A qualitative analysis
by: Erica Blum‐Barnett, et al.
Published: (2019-10-01)

Risk Factors Associated With Early-Onset Colorectal Neoplasm in Chinese Youth: A Prospective Population-Based Study
by: Jie Shen, et al.
Published: (2021-10-01)

Mutation Spectrum of Cancer-Associated Genes in Patients With Early Onset of Colorectal Cancer
by: Gulnur Zhunussova, et al.
Published: (2019-08-01)

Young-onset colorectal cancer in the North East of Scotland: survival, clinico-pathological features and genetics
by: Sarah Perrott, et al.
Published: (2020-02-01)

Clinical Manifestations and Amplitude-integrated Encephalogram in Neonates with Early-onset Epileptic Encephalopathy
by: Li-Li Liu, et al.
Published: (2017-01-01)

Early-Onset Schizophrenia Showed Similar but More Severe Olfactory Identification Impairment Than Adult-Onset Schizophrenia
by: Ze-tian Li, et al.
Published: (2020-06-01)

Architecture of Inherited Susceptibility to Colorectal Cancer: A Voyage of Discovery
by: Nicola Whiffin, et al.
Published: (2014-03-01)

Germline breast cancer susceptibility gene mutations and breast cancer outcomes
by: Yong Alison Wang, et al.
Published: (2018-03-01)

Bacterial isolates of early-onset neonatal sepsis and their antibiotic susceptibility pattern between 1998 and 2004: an audit from a center in India
by: KE Vandana, et al.
Published: (2011-07-01)

COX-2 gene rs689466 polymorphism is associated with increased risk of colorectal cancer among Caucasians: a meta-analysis
by: Yong-Chen Zhang, et al.
Published: (2020-07-01)

The impact of primary tumor sidedness on survival in early‐onset colorectal cancer by stage: A National Veterans Affairs retrospective analysis
by: Ibrahim Azar, et al.
Published: (2021-05-01)

Genomic Landscape of Young-Onset Bladder Cancer and Its Prognostic Implications on Adult Bladder Cancer
by: Sun-Wha Im, et al.
Published: (2020-01-01)

Association of emergence of new mutations in circulating tumuor DNA during chemotherapy with clinical outcome in metastatic colorectal cancer
by: Ning Jia, et al.
Published: (2021-07-01)

Effects of genetic variations in the Adiponectin pathway genes on the risk of colorectal cancer in the Chinese population
by: He Bangshun, et al.
Published: (2011-07-01)