hPMSCs inhibit the expression of PD-1 in CD4+IL-10+ T cells and mitigate liver damage in a GVHD mouse model by regulating the crosstalk between Nrf2 and NF-κB signaling pathway

hPMSCs inhibit the expression of PD-1 in CD4+IL-10+ T cells and mitigate liver damage in a GVHD mouse model by regulating the crosstalk between Nrf2 and NF-κB signaling pathway

Abstract Background The activation of T cells and imbalanced redox metabolism enhances the development of graft-versus-host disease (GVHD). Human placenta-derived mesenchymal stromal cells (hPMSCs) can improve GVHD through regulating T cell responses. However, whether hPMSCs balance the redox metabo...

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Bibliographic Details
Main Authors: Aiping Zhang, Jiashen Zhang, Xiaohua Li, Hengchao Zhang, Yanlian Xiong, Zhuoya Wang, Nannan Zhao, Feifei Wang, Xiying Luan
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Stem Cell Research & Therapy
Subjects:
Human placenta-derived mesenchymal stromal cells
Programmed death-1
CD4+IL-10+ T cells
Nuclear factor-E2-related factor 2
Nuclear factor kappa-B
Graft-versus-host disease
Online Access:https://doi.org/10.1186/s13287-021-02407-5

Internet

https://doi.org/10.1186/s13287-021-02407-5

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