Endogenous 3-Iodothyronamine (T1AM) and Synthetic Thyronamine-Like Analog SG-2 Act as Novel Pleiotropic Neuroprotective Agents through the Modulation of SIRT6

Endogenous 3-Iodothyronamine (T1AM) and Synthetic Thyronamine-Like Analog SG-2 Act as Novel Pleiotropic Neuroprotective Agents through the Modulation of SIRT6

3-iodothyronamine (T1AM) and the recently developed analog SG-2 are rapidly emerging as promising multi-target neuroprotective ligands able to reprogram lipid metabolism and to produce memory enhancement in mice. To elucidate the molecular mechanisms underlying the multi-target effects of these nove...

Full description

Bibliographic Details
Main Authors: Lorenza Bellusci, Massimiliano Runfola, Vittoria Carnicelli, Simona Sestito, Federica Fulceri, Filippo Santucci, Paola Lenzi, Francesco Fornai, Simona Rapposelli, Nicola Origlia, Riccardo Zucchi, Grazia Chiellini
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Molecules
Subjects:
3-iodothyronamine (t1am)
thyronamine-like analogs
multi-target directed ligand
neurodegeneration
sirt6
autophagy
ubiquitine-proteasome
long term potentiation (ltp)
mhapp mouse model
Online Access:https://www.mdpi.com/1420-3049/25/5/1054

Internet

https://www.mdpi.com/1420-3049/25/5/1054

Similar Items