Mapping the Multi-Organ miRNA-mRNA Regulatory Network in LPS-Mediated Endotoxemic Mice: Exploring the Shared Underlying Key Genes and Mechanisms

Mapping the Multi-Organ miRNA-mRNA Regulatory Network in LPS-Mediated Endotoxemic Mice: Exploring the Shared Underlying Key Genes and Mechanisms

BackgroundTo this day, the molecular mechanism of endotoxin-induced multi-organ failure has not been completely clarified. This study aimed to construct an miRNA-mRNA regulatory network and identify main pathways and key genes in multi-organ of LPS-mediated endotoxemic mice.MethodsPublic datasets fr...

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Bibliographic Details
Main Authors: Cong Zhang, Ying Liao, Zhihao Liu, Lijin Zeng, Zhihua Peng, Jinli Liao, Zhen Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Molecular Biosciences
Subjects:
lipopolysaccharide (LPS)
multi-organ damage
gene expression omnibus (GEO)
functional enrichment analysis
key genes
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2020.573327/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2020.573327/full

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