Inhibiting heat shock protein 90 (HSP90) limits the formation of liver cysts induced by conditional deletion of Pkd1 in mice.

Inhibiting heat shock protein 90 (HSP90) limits the formation of liver cysts induced by conditional deletion of Pkd1 in mice.

Polycystic liver disease (PLD) occurs in 75-90% of patients affected by autosomal dominant polycystic kidney disease (ADPKD), which affects 1∶400-1,000 adults and arises from inherited mutations in the PKD1 or PKD2 genes. PLD can lead to bile duct obstructions, infected or bleeding cysts, and hepato...

Full description

Bibliographic Details
Main Authors: Zachary B Smithline, Anna S Nikonova, Harvey H Hensley, Kathy Q Cai, Brian L Egleston, David A Proia, Tamina Seeger-Nukpezah, Erica A Golemis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4256400?pdf=render

Internet

http://europepmc.org/articles/PMC4256400?pdf=render

Similar Items