Evaluation of Engineered CRISPR-Cas-Mediated Systems for Site-Specific RNA Editing

Evaluation of Engineered CRISPR-Cas-Mediated Systems for Site-Specific RNA Editing

Summary: Site-directed RNA editing approaches offer great potential to correct genetic mutations in somatic cells while avoiding permanent off-target genomic edits. Nuclease-dead RNA-targeting CRISPR-Cas systems recruit functional effectors to RNA molecules in a programmable fashion. Here, we demons...

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Bibliographic Details
Main Authors: Ryan J. Marina, Kristopher W. Brannan, Kevin D. Dong, Brian A. Yee, Gene W. Yeo
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:Cell Reports
Subjects:
RNA editing
Cas9
Cas13
ADAR2
CRISPR
transcriptome engineering
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720313395

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http://www.sciencedirect.com/science/article/pii/S2211124720313395

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