Effect of Tryptophan-Derived AhR Ligands, Kynurenine, Kynurenic Acid and FICZ, on Proliferation, Cell Cycle Regulation and Cell Death of Melanoma Cells—In Vitro Studies

Effect of Tryptophan-Derived AhR Ligands, Kynurenine, Kynurenic Acid and FICZ, on Proliferation, Cell Cycle Regulation and Cell Death of Melanoma Cells—In Vitro Studies

Tryptophan metabolites: kynurenine (KYN), kynurenic acid (KYNA) and 6-formylindolo[3,2-b]carbazole (FICZ) are considered aryl hydrocarbon receptor (AhR) ligands. AhR is mainly expressed in barrier tissues, including skin, and is involved in various physiological and pathological processes in skin. W...

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Bibliographic Details
Main Authors: Katarzyna Walczak, Ewa Langner, Anna Makuch-Kocka, Monika Szelest, Karolina Szalast, Sebastian Marciniak, Tomasz Plech
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:International Journal of Molecular Sciences
Subjects:
tryptophan
kynurenine
kynurenic acid
FICZ
AhR
melanoma
Online Access:https://www.mdpi.com/1422-0067/21/21/7946

Internet

https://www.mdpi.com/1422-0067/21/21/7946

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