Anxiety and Startle Phenotypes in Glrb Spastic and Glra1 Spasmodic Mouse Mutants

Anxiety and Startle Phenotypes in Glrb Spastic and Glra1 Spasmodic Mouse Mutants

A GWAS study recently demonstrated single nucleotide polymorphisms (SNPs) in the human GLRB gene of individuals with a prevalence for agoraphobia. GLRB encodes the glycine receptor (GlyRs) β subunit. The identified SNPs are localized within the gene flanking regions (3′ and 5′ UTRs) and intronic reg...

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Bibliographic Details
Main Authors: Natascha Schaefer, Jérémy Signoret-Genest, Cora R. von Collenberg, Britta Wachter, Jürgen Deckert, Philip Tovote, Robert Blum, Carmen Villmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Molecular Neuroscience
Subjects:
glycine receptor
spastic
fear
anxiety
startle reaction
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2020.00152/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2020.00152/full

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