Exploring New Potential Anticancer Activities of the G-Quadruplexes Formed by [(GTG<sub>2</sub>T(G<sub>3</sub>T)<sub>3</sub>] and Its Derivatives with an Abasic Site Replacing Single Thymidine

Exploring New Potential Anticancer Activities of the G-Quadruplexes Formed by [(GTG<sub>2</sub>T(G<sub>3</sub>T)<sub>3</sub>] and Its Derivatives with an Abasic Site Replacing Single Thymidine

In this paper, we report our investigations on five T30175 analogues, prepared by replacing sequence thymidines with abasic sites (S) one at a time, in comparison to their natural counterpart in order to evaluate their antiproliferative potential and the involvement of the residues not belonging to...

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Bibliographic Details
Main Authors: Antonella Virgilio, Daniela Benigno, Annalisa Pecoraro, Annapina Russo, Giulia Russo, Veronica Esposito, Aldo Galeone
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
G-quadruplex
abasic site
aptamers
antiproliferative activity
Online Access:https://www.mdpi.com/1422-0067/22/13/7040

Internet

https://www.mdpi.com/1422-0067/22/13/7040

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