Uncoupling of invasive bacterial mucosal immunogenicity from pathogenicity

Uncoupling of invasive bacterial mucosal immunogenicity from pathogenicity

Virulent pathogens generally induce a stronger mucosal immunity than avirulent strains, but whether the associated inflammation is necessary for this is unclear. Here, using auxotrophic Salmonella enterica, the authors show that virulence factor function determines induction of protective IgA.

Bibliographic Details
Main Authors: Simona P. Pfister, Olivier P. Schären, Luca Beldi, Andrea Printz, Matheus D. Notter, Mohana Mukherjee, Hai Li, Julien P. Limenitakis, Joel P. Werren, Disha Tandon, Miguelangel Cuenca, Stefanie Hagemann, Stephanie S. Uster, Miguel A. Terrazos, Mercedes Gomez de Agüero, Christian M. Schürch, Fernanda M. Coelho, Roy Curtiss, Emma Slack, Maria L. Balmer, Siegfried Hapfelmeier
Format: Article
Language:English
Published: Nature Publishing Group 2020-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-15891-9

Internet

https://doi.org/10.1038/s41467-020-15891-9

Similar Items