PARK2 patient neuroprogenitors show increased mitochondrial sensitivity to copper

PARK2 patient neuroprogenitors show increased mitochondrial sensitivity to copper

Poorly-defined interactions between environmental and genetic risk factors underlie Parkinson's disease (PD) etiology. Here we tested the hypothesis that human stem cell derived forebrain neuroprogenitors from patients with known familial risk for early onset PD will exhibit enhanced sensitivit...

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Bibliographic Details
Main Authors: Asad A. Aboud, Andrew M. Tidball, Kevin K. Kumar, M. Diana Neely, Bingying Han, Kevin C. Ess, Charles C. Hong, Keith M. Erikson, Peter Hedera, Aaron B. Bowman
Format: Article
Language:English
Published: Elsevier 2015-01-01
Series:Neurobiology of Disease
Subjects:
PARK2
Neurotoxicty
Environmental risk factors
Parkinson's disease
Copper
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114002952

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http://www.sciencedirect.com/science/article/pii/S0969996114002952

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