Granulocyte-Derived Extracellular Vesicles Activate Monocytes and Are Associated With Mortality in Intensive Care Unit Patients

Granulocyte-Derived Extracellular Vesicles Activate Monocytes and Are Associated With Mortality in Intensive Care Unit Patients

To understand how extracellular vesicle (EV) subtypes differentially activate monocytes, a series of in vitro studies were performed. We found that plasma-EVs biased monocytes toward an M1 profile. Culturing monocytes with granulocyte-, monocyte-, and endothelial-EVs induced several pro-inflammatory...

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Bibliographic Details
Main Authors: Ali Danesh, Heather C. Inglis, Mohamed Abdel-Mohsen, Xutao Deng, Avril Adelman, Kenneth B. Schechtman, John W. Heitman, Ryan Vilardi, Avani Shah, Sheila M. Keating, Mitchell J. Cohen, Evan S. Jacobs, Satish K. Pillai, Jacques Lacroix, Philip C. Spinella, Philip J. Norris
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Immunology
Subjects:
extracellular vesicles
monocytes
granulocytes
exosomes
microvesicles
mortality
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00956/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00956/full

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