Axonal Dysfunction Precedes Motor Neuronal Death in Amyotrophic Lateral Sclerosis.

Axonal Dysfunction Precedes Motor Neuronal Death in Amyotrophic Lateral Sclerosis.

Wide-spread fasciculations are a characteristic feature in amyotrophic lateral sclerosis (ALS), suggesting motor axonal hyperexcitability. Previous excitability studies have shown increased nodal persistent sodium conductances and decreased potassium currents in motor axons of ALS patients, both of...

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Bibliographic Details
Main Authors: Yuta Iwai, Kazumoto Shibuya, Sonoko Misawa, Yukari Sekiguchi, Keisuke Watanabe, Hiroshi Amino, Satoshi Kuwabara
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4934877?pdf=render

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http://europepmc.org/articles/PMC4934877?pdf=render

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