CD4+ αβ T cell infiltration into the leptomeninges of lumbar dorsal roots contributes to the transition from acute to chronic mechanical allodynia after adult rat tibial nerve injuries

CD4+ αβ T cell infiltration into the leptomeninges of lumbar dorsal roots contributes to the transition from acute to chronic mechanical allodynia after adult rat tibial nerve injuries

Abstract Background Antigen-specific and MHCII-restricted CD4+ αβ T cells have been shown or suggested to play an important role in the transition from acute to chronic mechanical allodynia after peripheral nerve injuries. However, it is still largely unknown where these T cells infiltrate along the...

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Bibliographic Details
Main Authors: Bin Du, You-Quan Ding, Xia Xiao, Hong-Yi Ren, Bing-Yin Su, Jian-Guo Qi
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Journal of Neuroinflammation
Subjects:
Peripheral nerve injury
Neuropathic pain
Chronic pain
Mechanical allodynia
CD4+ αβ T cell
Dorsal root
Online Access:http://link.springer.com/article/10.1186/s12974-018-1115-7

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http://link.springer.com/article/10.1186/s12974-018-1115-7

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