High doses of ursodeoxycholic acid up-regulate the expression of placental breast cancer resistance protein in patients affected by intrahepatic cholestasis of pregnancy.

High doses of ursodeoxycholic acid up-regulate the expression of placental breast cancer resistance protein in patients affected by intrahepatic cholestasis of pregnancy.

Ursodeoxycholic acid (UDCA) administration in intrahepatic cholestasis of pregnancy (ICP) induces bile acids (BA) efflux from the foetal compartment, but the molecular basis of this transplacental transport is only partially defined.To determine if placental breast cancer resistance protein (BCRP),...

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Bibliographic Details
Main Authors: Francesco Azzaroli, Maria Elena Raspanti, Patrizia Simoni, Marco Montagnani, Andrea Lisotti, Paolo Cecinato, Rosario Arena, Giuliana Simonazzi, Antonio Farina, Nicola Rizzo, Giuseppe Mazzella
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3663799?pdf=render

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http://europepmc.org/articles/PMC3663799?pdf=render

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