Epitope-Based Chicken-Derived Novel Anti-PAD2 Monoclonal Antibodies Inhibit Citrullination

The aberrant upregulation of protein arginine deiminase 2- (PAD2-) catalyzed citrullination is reported in various autoimmune diseases (rheumatoid arthritis and multiple sclerosis) and several cancers. Currently, there are no anti-PAD2 monoclonal antibodies (mAbs) that can inhibit the citrullination...

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Bibliographic Details
Main Authors: Masayoshi Aosasa, Md Saddam Hossain, Tomoko Sakata, Keita Koga, Takanari Shigemitsu, Yuji Shoya, Motonori Yamaguchi, Kenji Saito, Mujo Kim
Format: Article
Language:English
Published: Hindawi Limited 2021-01-01
Series:Journal of Immunology Research
Online Access:http://dx.doi.org/10.1155/2021/6659960