Protein folding activity of ribosomal RNA is a selective target of two unrelated antiprion drugs.

Protein folding activity of ribosomal RNA is a selective target of two unrelated antiprion drugs.

6-Aminophenanthridine (6AP) and Guanabenz (GA, a drug currently in use for the treatment of hypertension) were isolated as antiprion drugs using a yeast-based assay. These structurally unrelated molecules are also active against mammalian prion in several cell-based assays and in vivo in a mouse mod...

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Bibliographic Details
Main Authors: Déborah Tribouillard-Tanvier, Suzana Dos Reis, Fabienne Gug, Cécile Voisset, Vincent Béringue, Raimon Sabate, Ema Kikovska, Nicolas Talarek, Stéphane Bach, Chenhui Huang, Nathalie Desban, Sven J Saupe, Surachai Supattapone, Jean-Yves Thuret, Stéphane Chédin, Didier Vilette, Hervé Galons, Suparna Sanyal, Marc Blondel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-05-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2374897?pdf=render

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http://europepmc.org/articles/PMC2374897?pdf=render

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