Copper/zinc chelation by clioquinol reduces spinal cord white matter damage and behavioral deficits in a murine MOG-induced multiple sclerosis model

Copper/zinc chelation by clioquinol reduces spinal cord white matter damage and behavioral deficits in a murine MOG-induced multiple sclerosis model

The present study aimed to evaluate the therapeutic potential of clioquinol (CQ), a metal chelator, on multiple sclerosis pathogenesis. Experimental autoimmune encephalomyelitis was induced by immunization with myelin oligodendrocyte glycoprotein (MOG(35–55)) in female mice. Three weeks after the in...

Full description

Bibliographic Details
Main Authors: Bo Young Choi, Bong Geom Jang, Jin Hee Kim, Jae-Nam Seo, Guang Wu, Min Sohn, Tae Nyoung Chung, Sang Won Suh
Format: Article
Language:English
Published: Elsevier 2013-06-01
Series:Neurobiology of Disease
Subjects:
Experimental autoimmune encephalomyelitis
Multiple sclerosis
Copper
Zinc
Microglia
BBB disruption
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996113000363

Internet

http://www.sciencedirect.com/science/article/pii/S0969996113000363

Similar Items