Dynamics of genome reorganization during human cardiogenesis reveal an RBM20-dependent splicing factory

The spatial organization of the genome plays an important but unclearly defined role in gene regulation. Here, the authors integrate Hi-C, RNA-seq and ATAC-seq data to map cardiogenesis from pluripotent stem cells and describe an RBM20-dependent splicing factory assembling the TTN locus with other R...

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Main Authors:	Alessandro Bertero, Paul A. Fields, Vijay Ramani, Giancarlo Bonora, Galip G. Yardimci, Hans Reinecke, Lil Pabon, William S. Noble, Jay Shendure, Charles E. Murry
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-04-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-09483-5

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spelling	doaj-a51e8f8741a942b2bf348aa7a7f3475f2021-05-11T12:05:39ZengNature Publishing GroupNature Communications2041-17232019-04-0110111910.1038/s41467-019-09483-5Dynamics of genome reorganization during human cardiogenesis reveal an RBM20-dependent splicing factoryAlessandro Bertero0Paul A. Fields1Vijay Ramani2Giancarlo Bonora3Galip G. Yardimci4Hans Reinecke5Lil Pabon6William S. Noble7Jay Shendure8Charles E. Murry9Department of Pathology, University of WashingtonDepartment of Pathology, University of WashingtonDepartment of Genome Sciences, University of WashingtonDepartment of Genome Sciences, University of WashingtonDepartment of Genome Sciences, University of WashingtonDepartment of Pathology, University of WashingtonDepartment of Pathology, University of WashingtonDepartment of Genome Sciences, University of WashingtonDepartment of Genome Sciences, University of WashingtonDepartment of Pathology, University of WashingtonThe spatial organization of the genome plays an important but unclearly defined role in gene regulation. Here, the authors integrate Hi-C, RNA-seq and ATAC-seq data to map cardiogenesis from pluripotent stem cells and describe an RBM20-dependent splicing factory assembling the TTN locus with other RBM20 targets.https://doi.org/10.1038/s41467-019-09483-5
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Alessandro Bertero Paul A. Fields Vijay Ramani Giancarlo Bonora Galip G. Yardimci Hans Reinecke Lil Pabon William S. Noble Jay Shendure Charles E. Murry
spellingShingle	Alessandro Bertero Paul A. Fields Vijay Ramani Giancarlo Bonora Galip G. Yardimci Hans Reinecke Lil Pabon William S. Noble Jay Shendure Charles E. Murry Dynamics of genome reorganization during human cardiogenesis reveal an RBM20-dependent splicing factory Nature Communications
author_facet	Alessandro Bertero Paul A. Fields Vijay Ramani Giancarlo Bonora Galip G. Yardimci Hans Reinecke Lil Pabon William S. Noble Jay Shendure Charles E. Murry
author_sort	Alessandro Bertero
title	Dynamics of genome reorganization during human cardiogenesis reveal an RBM20-dependent splicing factory
title_short	Dynamics of genome reorganization during human cardiogenesis reveal an RBM20-dependent splicing factory
title_full	Dynamics of genome reorganization during human cardiogenesis reveal an RBM20-dependent splicing factory
title_fullStr	Dynamics of genome reorganization during human cardiogenesis reveal an RBM20-dependent splicing factory
title_full_unstemmed	Dynamics of genome reorganization during human cardiogenesis reveal an RBM20-dependent splicing factory
title_sort	dynamics of genome reorganization during human cardiogenesis reveal an rbm20-dependent splicing factory
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-04-01
description	The spatial organization of the genome plays an important but unclearly defined role in gene regulation. Here, the authors integrate Hi-C, RNA-seq and ATAC-seq data to map cardiogenesis from pluripotent stem cells and describe an RBM20-dependent splicing factory assembling the TTN locus with other RBM20 targets.
url	https://doi.org/10.1038/s41467-019-09483-5
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Dynamics of genome reorganization during human cardiogenesis reveal an RBM20-dependent splicing factory

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