Isoflurane anesthesia precipitates tauopathy and upper airways dysfunction in pre-symptomatic Tau.P301L mice: Possible implication for neurodegenerative diseases

Isoflurane anesthesia precipitates tauopathy and upper airways dysfunction in pre-symptomatic Tau.P301L mice: Possible implication for neurodegenerative diseases

The postoperative cognitive decline resulting from volatile anesthesia is gaining acceptance as a major health problem. The common anesthetic isoflurane is suspected to precipitate neurodegeneration in Alzheimer's disease by unknown mechanisms. We previously validated that 8 month old Tau.P301L...

Full description

Bibliographic Details
Main Authors: Clément Menuet, Peter Borghgraef, Nicolas Voituron, Christian Gestreau, Lies Gielis, Herman Devijver, Mathias Dutschmann, Fred Van Leuven, Gérard Hilaire
Format: Article
Language:English
Published: Elsevier 2012-04-01
Series:Neurobiology of Disease
Subjects:
Tauopathy
Anesthesia
Upper airways
Memantine
Isoflurane
NMDA receptors
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996112000368

Internet

http://www.sciencedirect.com/science/article/pii/S0969996112000368

Similar Items