In silico molecular comparisons of C. elegans and mammalian pharmacology identify distinct targets that regulate feeding.

In silico molecular comparisons of C. elegans and mammalian pharmacology identify distinct targets that regulate feeding.

Phenotypic screens can identify molecules that are at once penetrant and active on the integrated circuitry of a whole cell or organism. These advantages are offset by the need to identify the targets underlying the phenotypes. Additionally, logistical considerations limit screening for certain phys...

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Bibliographic Details
Main Authors: George A Lemieux, Michael J Keiser, Maria F Sassano, Christian Laggner, Fahima Mayer, Roland J Bainton, Zena Werb, Bryan L Roth, Brian K Shoichet, Kaveh Ashrafi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-11-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC3833878?pdf=render

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http://europepmc.org/articles/PMC3833878?pdf=render

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