Serpins in Hemostasis as Therapeutic Targets for Bleeding or Thrombotic Disorders

Serpins in Hemostasis as Therapeutic Targets for Bleeding or Thrombotic Disorders

Bleeding and thrombotic disorders result from imbalances in coagulation or fibrinolysis, respectively. Inhibitors from the serine protease inhibitor (serpin) family have a key role in regulating these physiological events, and thus stand out as potential therapeutic targets for modulating fibrin clo...

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Bibliographic Details
Main Authors: Elsa P. Bianchini, Claire Auditeau, Mahita Razanakolona, Marc Vasse, Delphine Borgel
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
serpin (serine proteinase inhibitor)
antithrombin (AT)
protein Z-dependent protease inhibitor (ZPI)
plasminogen activator inhibitor 1 (PAI-1)
therapy
protease nexin I (PN-1)
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2020.622778/full

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https://www.frontiersin.org/articles/10.3389/fcvm.2020.622778/full

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