Serpins in Hemostasis as Therapeutic Targets for Bleeding or Thrombotic Disorders

• Main Authors: Elsa P. Bianchini, Claire Auditeau, Mahita Razanakolona, Marc Vasse, Delphine Borgel
• Format: Article
• Language: English
• Published: Frontiers Media S.A. 2021-01-01
• Series: Frontiers in Cardiovascular Medicine
• Subjects: serpin (serine proteinase inhibitor); antithrombin (AT); protein Z-dependent protease inhibitor (ZPI); plasminogen activator inhibitor 1 (PAI-1); therapy; protease nexin I (PN-1)
• Online Access: https://www.frontiersin.org/articles/10.3389/fcvm.2020.622778/full
• ISSN: 2297-055X

Bleeding and thrombotic disorders result from imbalances in coagulation or fibrinolysis, respectively. Inhibitors from the serine protease inhibitor (serpin) family have a key role in regulating these physiological events, and thus stand out as potential therapeutic targets for modulating fibrin clot formation or dismantling. Here, we review the diversity of serpin-targeting strategies in the area of hemostasis, and detail the suggested use of modified serpins and serpin inhibitors (ranging from small-molecule drugs to antibodies) to treat or prevent bleeding or thrombosis.