Leptin Downregulates LPS-Induced Lung Injury: Role of Corticosterone and Insulin

Leptin Downregulates LPS-Induced Lung Injury: Role of Corticosterone and Insulin

Background/Aims: We investigated the effects of leptin in the development of lipopolysaccharide (LPS)-induced acute lung inflammation (ALI) in lean mice. Methods: Mice were administered leptin (1.0µg/g) or leptin (1.0µg/g) followed by LPS (1.5µg/g) intranasally. Additionally, some animals were given...

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Bibliographic Details
Main Authors: Maristella A. Landgraf, Reinaldo C. Silva, Matheus Corrêa-Costa, Meire I. Hiyane, Maria Helena C. Carvalho, Richardt G. Landgraf, Niels O.S. Câmara
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2014-03-01
Series:Cellular Physiology and Biochemistry
Subjects:
Insulin, corticosterone, acute lung injury
Lipopolysaccharide
Lung inflammation
Leptin
Online Access:http://www.karger.com/Article/FullText/358656

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http://www.karger.com/Article/FullText/358656

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