SHP1 Regulates Bone Mass by Directing Mesenchymal Stem Cell Differentiation

SHP1 Regulates Bone Mass by Directing Mesenchymal Stem Cell Differentiation

Osteoblasts and adipocytes are derived from a common precursor, mesenchymal stem cells (MSCs). Alterations in the normal fate of differentiating MSCs are involved in the development of obesity and osteoporosis. Here, we report that viable motheaten (mev) mice, which are deficient in the SH2-domain-c...

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Bibliographic Details
Main Authors: Menghui Jiang, Chunxing Zheng, Peishun Shou, Na Li, Gang Cao, Qing Chen, Chunliang Xu, Liming Du, Qian Yang, Jianchang Cao, Yanyan Han, Fengying Li, Wei Cao, Feng Liu, Arnold B. Rabson, Arthur I. Roberts, Weifen Xie, Ying Wang, Yufang Shi
Format: Article
Language:English
Published: Elsevier 2016-07-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716307756

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http://www.sciencedirect.com/science/article/pii/S2211124716307756

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