Disease propagation in amyotrophic lateral sclerosis (ALS): an interplay between genetics and environment

Disease propagation in amyotrophic lateral sclerosis (ALS): an interplay between genetics and environment

Abstract Amyotrophic lateral sclerosis (ALS) is a progressive, fatal disease affecting the neuromuscular system. While there have been a number of important genetic discoveries, there are no therapeutics capable of stopping its insidious progression. Lessons from clinical histories reveal that ALS c...

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Bibliographic Details
Main Authors: Sarah Schram, Jeffrey A. Loeb, Fei Song
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Journal of Neuroinflammation
Subjects:
Nerve injury-mediated neuroinflammation
Neuronal-glial communication through glial growth factor neuregulin
Inhibition of neuregulin-mediated inflammation
Online Access:http://link.springer.com/article/10.1186/s12974-020-01849-7

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http://link.springer.com/article/10.1186/s12974-020-01849-7

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