Protective role of the alpha-1-antitrypsin in intervertebral disc degeneration

Abstract Background Intervertebral disc degeneration is a complex disease with high prevalence. It suggests that cell death, senescence, and extracellular matrix degradation are involved in the pathogenesis. Alpha-1 antitrypsin (AAT), a serine protease inhibitor, was previously correlated with infla...

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Bibliographic Details
Main Authors: Weikun Liu, Yanfu Wang
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Online Access:https://doi.org/10.1186/s13018-021-02668-z