Mutant KRAS triggers functional reprogramming of tumor-associated macrophages in colorectal cancer

Mutant KRAS triggers functional reprogramming of tumor-associated macrophages in colorectal cancer

Abstract Oncogenic KRAS has been previously identified to act in a cell-intrinsic manner to modulate multiple biological functions of colorectal cancer (CRC). Here, we demonstrate a cell-extrinsic role of KRAS, where KRAS engages with the tumor microenvironment by functional reprogramming of tumor-a...

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Bibliographic Details
Main Authors: Huashan Liu, Zhenxing Liang, Chi Zhou, Ziwei Zeng, Fengwei Wang, Tuo Hu, Xiaowen He, Xiaojian Wu, Xianrui Wu, Ping Lan
Format: Article
Language:English
Published: Nature Publishing Group 2021-04-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-021-00534-2

Internet

https://doi.org/10.1038/s41392-021-00534-2

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