Histone deacetylase inhibitors selectively target homology dependent DNA repair defective cells and elevate non-homologous endjoining activity.

Histone deacetylase inhibitors selectively target homology dependent DNA repair defective cells and elevate non-homologous endjoining activity.

We have previously used the ATAD5-luciferase high-throughput screening assay to identify genotoxic compounds with potential chemotherapeutic capabilities. The successful identification of known genotoxic agents, including the histone deacetylase inhibitor (HDACi) trichostatin A (TSA), confirmed the...

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Bibliographic Details
Main Authors: Stephanie Smith, Jennifer Fox, Marco Mejia, Wanvipa Ruangpradit, Alihossein Saberi, Sunmi Kim, Yongjun Choi, Sehyun Oh, Yucai Wang, Kyungho Choi, Lei Li, Eric A Hendrickson, Shunichi Takeda, Mark Muller, Kyungjae Myung
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3900704?pdf=render

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http://europepmc.org/articles/PMC3900704?pdf=render

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