The Role of High-Resolution Analytical Techniques in the Development of Functional Foods
The approaches based on high-resolution analytical techniques, such as nuclear magnetic resonance or mass spectrometry coupled to chromatographic techniques, have a determining role in several of the stages necessary for the development of functional foods. The analyses of botanical extracts rich in...
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doaj-a53b7bbaadeb44f3a6c074bb352550d92021-03-23T00:03:25ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-03-01223220322010.3390/ijms22063220The Role of High-Resolution Analytical Techniques in the Development of Functional FoodsÁlvaro Fernández-Ochoa0Francisco Javier Leyva-Jiménez1María de la Luz Cádiz-Gurrea2Sandra Pimentel-Moral3Antonio Segura-Carretero4Max Delbrück Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, GermanyFunctional Food Research and Development Center, Health Science Technological Park, Avenida del Conocimiento s/n, E-18100 Granada, SpainFunctional Food Research and Development Center, Health Science Technological Park, Avenida del Conocimiento s/n, E-18100 Granada, SpainDepartment of Analytical Chemistry, Faculty of Sciences, University of Granada, Fuentenueva s/n, E-18071 Granada, SpainFunctional Food Research and Development Center, Health Science Technological Park, Avenida del Conocimiento s/n, E-18100 Granada, SpainThe approaches based on high-resolution analytical techniques, such as nuclear magnetic resonance or mass spectrometry coupled to chromatographic techniques, have a determining role in several of the stages necessary for the development of functional foods. The analyses of botanical extracts rich in bioactive compounds is one of the fundamental steps in order to identify and quantify their phytochemical composition. However, the compounds characterized in the extracts are not always responsible for the bioactive properties because they generally undergo metabolic reactions before reaching the therapeutic targets. For this reason, analytical techniques are also applied to analyze biological samples to know the bioavailability, pharmacokinetics and/or metabolism of the compounds ingested by animal or human models in nutritional intervention studies. In addition, these studies have also been applied to determine changes of endogenous metabolites caused by prolonged intake of compounds with bioactive potential. This review aims to describe the main types and modes of application of high-resolution analytical techniques in all these steps for functional food development.https://www.mdpi.com/1422-0067/22/6/3220analytical techniquesanalytical chemistrychromatographyfunctional foodmass spectrometrynuclear magnetic resonance |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Álvaro Fernández-Ochoa Francisco Javier Leyva-Jiménez María de la Luz Cádiz-Gurrea Sandra Pimentel-Moral Antonio Segura-Carretero |
spellingShingle |
Álvaro Fernández-Ochoa Francisco Javier Leyva-Jiménez María de la Luz Cádiz-Gurrea Sandra Pimentel-Moral Antonio Segura-Carretero The Role of High-Resolution Analytical Techniques in the Development of Functional Foods International Journal of Molecular Sciences analytical techniques analytical chemistry chromatography functional food mass spectrometry nuclear magnetic resonance |
author_facet |
Álvaro Fernández-Ochoa Francisco Javier Leyva-Jiménez María de la Luz Cádiz-Gurrea Sandra Pimentel-Moral Antonio Segura-Carretero |
author_sort |
Álvaro Fernández-Ochoa |
title |
The Role of High-Resolution Analytical Techniques in the Development of Functional Foods |
title_short |
The Role of High-Resolution Analytical Techniques in the Development of Functional Foods |
title_full |
The Role of High-Resolution Analytical Techniques in the Development of Functional Foods |
title_fullStr |
The Role of High-Resolution Analytical Techniques in the Development of Functional Foods |
title_full_unstemmed |
The Role of High-Resolution Analytical Techniques in the Development of Functional Foods |
title_sort |
role of high-resolution analytical techniques in the development of functional foods |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1661-6596 1422-0067 |
publishDate |
2021-03-01 |
description |
The approaches based on high-resolution analytical techniques, such as nuclear magnetic resonance or mass spectrometry coupled to chromatographic techniques, have a determining role in several of the stages necessary for the development of functional foods. The analyses of botanical extracts rich in bioactive compounds is one of the fundamental steps in order to identify and quantify their phytochemical composition. However, the compounds characterized in the extracts are not always responsible for the bioactive properties because they generally undergo metabolic reactions before reaching the therapeutic targets. For this reason, analytical techniques are also applied to analyze biological samples to know the bioavailability, pharmacokinetics and/or metabolism of the compounds ingested by animal or human models in nutritional intervention studies. In addition, these studies have also been applied to determine changes of endogenous metabolites caused by prolonged intake of compounds with bioactive potential. This review aims to describe the main types and modes of application of high-resolution analytical techniques in all these steps for functional food development. |
topic |
analytical techniques analytical chemistry chromatography functional food mass spectrometry nuclear magnetic resonance |
url |
https://www.mdpi.com/1422-0067/22/6/3220 |
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