Distinctive Behaviors of Druggable Proteins in Cellular Networks.

The interaction environment of a protein in a cellular network is important in defining the role that the protein plays in the system as a whole, and thus its potential suitability as a drug target. Despite the importance of the network environment, it is neglected during target selection for drug d...

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Bibliographic Details
Main Authors: Costas Mitsopoulos, Amanda C Schierz, Paul Workman, Bissan Al-Lazikani
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-12-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1004597