Apremilast Regulates the Teff/Treg Balance to Ameliorate Uveitis via PI3K/AKT/FoxO1 Signaling Pathway

Apremilast Regulates the Teff/Treg Balance to Ameliorate Uveitis via PI3K/AKT/FoxO1 Signaling Pathway

Autoimmune uveitis (AU), being one of the sight-threatening ocular inflammatory disorders, has been widely regarded by ophthalmologists and immunologists as a great challenge. Apremilast, a phosphodiesterase-4 inhibitor (PDE4i), which was approved by the U.S. Food and Drug Administration (FDA) for t...

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Bibliographic Details
Main Authors: Yuxi Chen, Zhuang Li, He Li, Wenru Su, Yanyan Xie, Yuan Pan, Xiaoqing Chen, Dan Liang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Immunology
Subjects:
apremilast
uveitis
PI3K/AKT/FoxO1 signal pathway
Teff/Treg
PDE4
experimental autoimmune uveitis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.581673/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2020.581673/full

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