Advanced glycation end product cross-link breaker attenuates diabetes-induced cardiac dysfunction by improving sarcoplasmic reticulum calcium handling

Advanced glycation end product cross-link breaker attenuates diabetes-induced cardiac dysfunction by improving sarcoplasmic reticulum calcium handling

Diabetic heart disease is a distinct clinical entity that can progress to heart failure and sudden death. However, the mechanisms responsible for the alterations in excitation-contraction coupling leading to cardiac dysfunction during diabetes are not well known. Hyperglycemia, the landmark of diabe...

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Bibliographic Details
Main Authors: Allyson eKranstuber, Carlos edel Rio, Brandon eBiesiadecki, Robert eHamlin, Joseph eOttobre, Sandor eGyorke, Véronique A. Lacombe
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-07-01
Series:Frontiers in Physiology
Subjects:
type 1 diabetes
cardiomyopathy
Alagebrium Chloride
Diastolic function
Sarcoplasmic reticulum Ca-ATPase Pump
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00292/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00292/full

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