Depolarization controls TRAIL sensitization and tumor-selective killing of cancer cells: crosstalk with ROS

Depolarization controls TRAIL sensitization and tumor-selective killing of cancer cells: crosstalk with ROS

Conventional genotoxic anti-cancer drugs target the proliferative advantage of tumor cells over normal cells. This kind of approach lacks the selectivity of treatment to cancer cells, because most of the targeted pathways are essential for the survival of normal cells. As a result, traditional cance...

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Bibliographic Details
Main Authors: Yoshihiro eSuzuki-Karasaki, Miki eSuzuki-Karasaki, Mayumi eUchida, Toyoko eOchiai
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-05-01
Series:Frontiers in Oncology
Subjects:
Apoptosis
Endoplasmic Reticulum Stress
Mitochondria
Oxidative Stress
ROS
TRAIL
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00128/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00128/full

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