Immune-complex mimics as a molecular platform for adjuvant-free vaccine delivery.

Immune-complex mimics as a molecular platform for adjuvant-free vaccine delivery.

Protein-based vaccine development faces the difficult challenge of finding robust yet non-toxic adjuvants suitable for humans. Here, using a molecular engineering approach, we have developed a molecular platform for generating self-adjuvanting immunogens that do not depend on exogenous adjuvants for...

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Bibliographic Details
Main Authors: Ilaria Pepponi, Elena Stylianou, Craig van Dolleweerd, Gil Reynolds Diogo, Matthew J Paul, Pascal M W Drake, Julian K-C Ma, Rajko Reljic
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3634044?pdf=render

Internet

http://europepmc.org/articles/PMC3634044?pdf=render

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