The dynamics of early-state transcriptional changes and aggregate formation in a Huntington’s disease cell model

The dynamics of early-state transcriptional changes and aggregate formation in a Huntington’s disease cell model

Abstract Background Huntington’s disease (HD) is a fatal neurodegenerative disorder caused by a CAG expansion in the Huntingtin (HTT) gene. Proteolytic cleavage of mutant huntingtin (Htt) protein with an expanded polyglutamine (polyQ) stretch results in production of Htt fragments that aggregate and...

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Bibliographic Details
Main Authors: Martijn van Hagen, Diewertje G. E. Piebes, Wim C. de Leeuw, Ilona M. Vuist, Willeke M. C. van Roon-Mom, Perry D. Moerland, Pernette J. Verschure
Format: Article
Language:English
Published: BMC 2017-05-01
Series:BMC Genomics
Subjects:
Huntington's disease
Transcription
Aggregates
Inducible HD cell line
Early HD cellular phenotype
Temporal analysis
Online Access:http://link.springer.com/article/10.1186/s12864-017-3745-z

Internet

http://link.springer.com/article/10.1186/s12864-017-3745-z

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