Human COQ9 Rescues a coq9 Yeast Mutant by Enhancing Coenzyme Q Biosynthesis from 4-Hydroxybenzoic Acid and Stabilizing the CoQ-Synthome

Human COQ9 Rescues a coq9 Yeast Mutant by Enhancing Coenzyme Q Biosynthesis from 4-Hydroxybenzoic Acid and Stabilizing the CoQ-Synthome

Coq9 is required for the stability of a mitochondrial multi-subunit complex, termed the CoQ-synthome, and the deamination step of Q intermediates that derive from para-aminobenzoic acid (pABA) in yeast. In human, mutations in the COQ9 gene cause neonatal-onset primary Q10 deficiency. In this study,...

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Bibliographic Details
Main Authors: Cuiwen H. He, Dylan S. Black, Christopher M. Allan, Brigitte Meunier, Shamima Rahman, Catherine F. Clarke
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-07-01
Series:Frontiers in Physiology
Subjects:
human homolog
temperature-sensitive mutant
coenzyme Q
immunoprecipitation
Saccharomyces cerevisiae
mitochondrial metabolism
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2017.00463/full

Internet

http://journal.frontiersin.org/article/10.3389/fphys.2017.00463/full

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