Activation of HIFa pathway in mature osteoblasts disrupts the integrity of the osteocyte/canalicular network.

Activation of HIFa pathway in mature osteoblasts disrupts the integrity of the osteocyte/canalicular network.

The hypoxia-inducible factors (HIFs), HIF-1α and HIF-2α, are the central mediators of the homeostatic response that enables cells to survive and differentiate in low-oxygen conditions. Previous studies indicated that disruption of the von Hippel-Lindau gene (Vhl) coincides with the activation of HIF...

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Main Authors: Gui-lai Zuo, Lian-fang Zhang, Jin Qi, Hui Kang, Peng Jia, Hao Chen, Xing Shen, Lei Guo, Han-bing Zhou, Jin-shen Wang, Qi Zhou, Nian-dong Qian, Lian-fu Deng
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4373796?pdf=render

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http://europepmc.org/articles/PMC4373796?pdf=render

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