Proteomic Analysis Reveals Autophagy as Pro-Survival Pathway Elicited by Long-Term Exposure with 5-Azacitidine in High-Risk Myelodysplasia

Proteomic Analysis Reveals Autophagy as Pro-Survival Pathway Elicited by Long-Term Exposure with 5-Azacitidine in High-Risk Myelodysplasia

Azacytidine (5-AZA) is the standard first-choice treatment for high-risk myelodysplasia (MDS) patients. However, the clinical outcome for those patients who interrupt treatment or whose disease failed to respond is very poor. In order to identify the cellular pathways that are modified by long-term...

Full description

Bibliographic Details
Main Authors: Alessandra Romano, Cesarina Giallongo, Piera La Cava, Nunziatina L. Parrinello, Antonella Chiechi, Calogero Vetro, Daniele Tibullo, Francesco Di Raimondo, Lance A. Liotta, Virginia Espina, Giuseppe A. Palumbo
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-04-01
Series:Frontiers in Pharmacology
Subjects:
myelodysplastic syndrome
azacytidine
autophagy
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00204/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00204/full

Similar Items