High dose acetaminophen inhibits STAT3 and has free radical independent anti-cancer stem cell activity

High dose acetaminophen inhibits STAT3 and has free radical independent anti-cancer stem cell activity

High-dose acetaminophen (AAP) with delayed rescue using n-acetylcysteine (NAC), the FDA-approved antidote to AAP overdose, has demonstrated promising antitumor efficacy in early phase clinical trials. However, the mechanism of action (MOA) of AAP's anticancer effects remains elusive. Using clin...

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Bibliographic Details
Main Authors: Pavani Pingali, Y. Jeffrey Wu, Rio Boothello, Chetna Sharon, Howard Li, Srinivas Sistla, Nehru Viji Sankaranarayanan, Umesh R. Desai, Anh T. Le, Robert C. Doebele, Leslie L. Muldoon, Bhaumik B. Patel, Alexander Neuwelt
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Acetaminophen
N-acetylcysteine
STAT3
Cancer stem cells
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558621000075

Internet

http://www.sciencedirect.com/science/article/pii/S1476558621000075

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