Identification of abscission checkpoint bodies as structures that regulate ESCRT factors to control abscission timing

Identification of abscission checkpoint bodies as structures that regulate ESCRT factors to control abscission timing

The abscission checkpoint regulates the ESCRT membrane fission machinery and thereby delays cytokinetic abscission to protect genomic integrity in response to residual mitotic errors. The checkpoint is maintained by Aurora B kinase, which phosphorylates multiple targets, including CHMP4C, a regulato...

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Bibliographic Details
Main Authors: Lauren K Williams, Douglas R Mackay, Madeline A Whitney, Genevieve C Couldwell, Wesley I Sundquist, Katharine S Ullman
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-08-01
Series:eLife
Subjects:
abscission
cell division
ESCRT pathway
cytokinesis
Online Access:https://elifesciences.org/articles/63743

Internet

https://elifesciences.org/articles/63743

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