Cocaine Reduces the Neuronal Population While Upregulating Dopamine D2-Receptor-Expressing Neurons in Brain Reward Regions: Sex-Effects

Cocaine Reduces the Neuronal Population While Upregulating Dopamine D2-Receptor-Expressing Neurons in Brain Reward Regions: Sex-Effects

Addiction to cocaine is associated with dysfunction of the dopamine mesocortical system including impaired dopamine-2 receptor (D2r) signaling. However, the effects of chronic cocaine on neuronal adaptations in this system have not been systematically examined and data available is mostly from males...

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Bibliographic Details
Main Authors: Kevin Clare, Chelsea Pan, Gloria Kim, Kicheon Park, Juan Zhao, Nora D. Volkow, Zhicheng Lin, Congwu Du
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Pharmacology
Subjects:
cocaine
dopamine-2 receptor
dynorphin
enkephalin
neuroadaptation
sex differences
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.624127/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.624127/full

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