Melatonin decreases M1 polarization via attenuating mitochondrial oxidative damage depending on UCP2 pathway in prorenin-treated microglia.

Melatonin decreases M1 polarization via attenuating mitochondrial oxidative damage depending on UCP2 pathway in prorenin-treated microglia.

Accumulating evidence suggests that neuroinflammation and oxidative stress in cardiovascular center contribute to the pathological processes underlying hypertension. Microglia activation triggers the inflammation and oxidative stress. Melatonin is a documented potent anti-inflammatory regent and ant...

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Bibliographic Details
Main Authors: Li Hu, Shutian Zhang, Haoyu Wen, Tianfeng Liu, Jian Cai, Dongshu Du, Danian Zhu, Fuxue Chen, Chunmei Xia
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0212138

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https://doi.org/10.1371/journal.pone.0212138

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