The Production of Testosterone and Gene Expression in Neonatal Testes of Rats Exposed to Diisoheptyl Phthalate During Pregnancy is Inhibited

The Production of Testosterone and Gene Expression in Neonatal Testes of Rats Exposed to Diisoheptyl Phthalate During Pregnancy is Inhibited

Background: Diisoheptyl phthalate (DIHP) is a phthalate plasticizer, which is a branched phthalate. Here, we reported the effects of gestational exposure to DIHP on testis development in male rats.Methods: Pregnant Sprague-Dawley rats were orally fed with vehicle (corn oil, control) or DIHP (10, 100...

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Bibliographic Details
Main Authors: Bin Ji, Zina Wen, Chaobo Ni, Qiqi Zhu, Yiyan Wang, Xiaoheng Li, Ying Zhong, Ren-Shan Ge
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Pharmacology
Subjects:
diisoheptyl phthalate
fetal leydig cell
testis dysgenesis
leydig cell cluster
multinucleated gonocytes
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.568311/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.568311/full

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