Substrate topography determines neuronal polarization and growth in vitro.

The establishment of neuronal connectivity depends on the correct initial polarization of the young neurons. In vivo, developing neurons sense a multitude of inputs and a great number of molecules are described that affect their outgrowth. In vitro, many studies have shown the possibility to influen...

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Bibliographic Details
Main Authors: Liesbeth Micholt, Annette Gärtner, Dimiter Prodanov, Dries Braeken, Carlos G Dotti, Carmen Bartic
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3681759?pdf=render