Protective mechanism of artemisinin on rat bone marrow-derived mesenchymal stem cells against apoptosis induced by hydrogen peroxide via activation of c-Raf-Erk1/2-p90rsk-CREB pathway

Protective mechanism of artemisinin on rat bone marrow-derived mesenchymal stem cells against apoptosis induced by hydrogen peroxide via activation of c-Raf-Erk1/2-p90rsk-CREB pathway

Abstract Background Bone marrow-derived mesenchymal stem cell (BMSC) transplantation is one of the new therapeutic strategies for treating ischemic brain and heart tissues. However, the poor survival rate of transplanted BMSCs in ischemic tissue, due to high levels of reactive oxygen species (ROS),...

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Bibliographic Details
Main Authors: Jiankang Fang, Xia Zhao, Shuai Li, Xingan Xing, Haitao Wang, Philip Lazarovici, Wenhua Zheng
Format: Article
Language:English
Published: BMC 2019-10-01
Series:Stem Cell Research & Therapy
Subjects:
Artemisinin
Bone marrow mesenchymal stem cells
Apoptosis
ROS
Erk1/2
Raf
Online Access:http://link.springer.com/article/10.1186/s13287-019-1419-2

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http://link.springer.com/article/10.1186/s13287-019-1419-2

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