The IgA Isotype of Anti-β2 Glycoprotein I Antibodies Recognizes Epitopes in Domains 3, 4, and 5 That Are Located in a Lateral Zone of the Molecule (L-Shaped)

The IgA Isotype of Anti-β2 Glycoprotein I Antibodies Recognizes Epitopes in Domains 3, 4, and 5 That Are Located in a Lateral Zone of the Molecule (L-Shaped)

Background: Antiphospholipid syndrome (APS) is characterized by thrombosis and/or pregnancy morbidity with presence of anti-phospholipid antibodies (aPL). The APS classification criteria only consider the aPL of IgG/IgM isotype, however testing of aPL of IgA isotype is recommended when APS is suspec...

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Bibliographic Details
Main Authors: Manuel Serrano, Jose Angel Martinez-Flores, Gary L. Norman, Laura Naranjo, Jose Maria Morales, Antonio Serrano
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Immunology
Subjects:
antiphospholipid antibodies
antiphospholipid syndrome
kidney transplant
graft thrombosis
epitope mapping
peptide arrays
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01031/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.01031/full

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