Cathepsin K Deficiency Prevents the Aggravated Vascular Remodeling Response to Flow Cessation in ApoE-/- Mice.

Cathepsin K Deficiency Prevents the Aggravated Vascular Remodeling Response to Flow Cessation in ApoE-/- Mice.

Cathepsin K (catK) is a potent lysosomal cysteine protease involved in extracellular matrix (ECM) degradation and inflammatory remodeling responses. Here we have investigated the contribution of catK deficiency on carotid arterial remodeling in response to flow cessation in apoE-/- and wild type (wt...

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Bibliographic Details
Main Authors: Marjo M P C Donners, Lili Bai, Suzanne P M Lutgens, Erwin Wijnands, Jason Johnson, Leon J Schurgers, Cong-Lin Liu, Mat J A P Daemen, Kitty B J M Cleutjens, Guo-Ping Shi, Erik A L Biessen, Sylvia Heeneman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5026377?pdf=render

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http://europepmc.org/articles/PMC5026377?pdf=render

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