Heterogeneous Mechanisms of Secondary Resistance and Clonal Selection in Sarcoma during Treatment with Nutlin.

Heterogeneous Mechanisms of Secondary Resistance and Clonal Selection in Sarcoma during Treatment with Nutlin.

Nutlin inhibits TP53-MDM2 interaction and is under investigation in soft-tissue sarcomas (STS) and other malignancies. Molecular mechanisms of secondary resistance to nutlin in STS are unknown. We performed whole-transcriptome sequencing (RNA-seq) on three pretreatment and secondary resistant STS ce...

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Main Authors: Audrey Laroche, Kevin Tran-Cong, Vanessa Chaire, Pauline Lagarde, Isabelle Hostein, Jean-Michel Coindre, Frederic Chibon, Agnes Neuville, Tom Lesluyes, Carlo Lucchesi, Antoine Italiano
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4591276?pdf=render

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http://europepmc.org/articles/PMC4591276?pdf=render

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