From Human Megakaryocytes to Platelets: Effects of Aspirin on High-Mobility Group Box 1/Receptor for Advanced Glycation End Products Axis

From Human Megakaryocytes to Platelets: Effects of Aspirin on High-Mobility Group Box 1/Receptor for Advanced Glycation End Products Axis

Platelets (PLTs) are the major source of high-mobility group box 1 (HMGB1), a protein that is involved in sterile inflammation of blood vessels and thrombosis. Megakaryocytes (MKs) synthesize HMGB1 and transfer both protein and mRNA into PLTs and PLT-derived microvesicles (MV). Free HMGB1 found in s...

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Bibliographic Details
Main Authors: Stefania Mardente, Emanuela Mari, Isabella Massimi, Marco Tafani, Raffaella Guerriero, Ornella Morsilli, Fabio M. Pulcinelli, Marco E. Bianchi, Alessandra Zicari
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Immunology
Subjects:
aspirin
platelets
megakaryocytes
high-mobility group box 1
receptor for advanced glycation end products
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01946/full

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http://journal.frontiersin.org/article/10.3389/fimmu.2017.01946/full

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